Data Explorer
Browse complete candidate gene lists, filtering funnels, and raw data for each cancer type.
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Total Genes Tested
protein-coding input
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ML Signature
top importance genes
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Germline Conserved
dN/dS < 0.3
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Final Candidates
all filters passed
See Key Findings for the full filtering pipeline visualization.
Candidate Genes
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Filtering thresholds:
germline dN/dS < 0.3, somatic dN/dS ≥ 1.5, FDR q < 0.05.
CI lower bound > 1.0 required.
UCEC candidate inflation: UCEC's elevated tumour mutation burden
(median 37 nonsyn/gene) inflates the number of genes reaching statistical significance.
TMB-adaptive FDR (q < 0.01) partially addresses this, but the 116 UCEC candidates
should be interpreted cautiously compared to other cancer types.